thickened and covered with a deposit resembling tough, coagulated lymph. The heart was found distended with blood. Eight hundredths of a cubic centimetre of the same solution failed in the first experiment to kill in two weeks, though the frog remained in rather a depressed condition. At the end of that time it was killed, and marked local changes, such as those described, were found. Of two other frogs which received the same amount (0.08 c. cm.), one died after two days ; the other was

more »

... d on the fifth day. The solutions in which the phosphorus had been soaking were then given in the same dose (0.08 c. cm.) to two frogs, with results not differing materially in any --1 The experiments above recorded were performed, through the kindness of Professor H. P. Bowditch, in the physiological laboratory of Harvard Medical School. Jaborandi.2-The action of this drug has been explained by M. Gubler as follows : Jaborandi acts directly upon the cells in the salivary glands. From the very moment of its ingestion, these secretory cells are excited, and immediately a stimulation of the distal ends of the centripetal nerves ensues. This stimulation is transmitted to the reflecting centres,