Episodic angioedema associated with eosinophilia

Fang Liu, Wenxing Hu, Haibo Liu, Min Zhang, Hong Sang
2017 Anais Brasileiros de Dermatologia  
We report a 12-year-old girl who presented with recurrent angioedema on the face, trunk, and extremities, and concomitant marked weight gain for 5 years. During the episode, her white blood cell count increased to 47.7×109/L with 89.9% eosinophils, followed by elevated serum level of IL-5, IgE, IgM, and LDH. Histopathology showed perivascular eosinophilic infiltration and diffuse eosinophilic infiltration throughout the dermis. Possible causes of hypereosinophilia and eosinophilic infiltration
more » ... f vital organs were ruled out. We also tested the FIP1L1/PDGFRa and ETV6/PDGFRβ fusion gene to exclude the possibility of myeloid and lymphatic vessel neoplasms. The patient was treated with methylprednisolone and discharged with an oral prednisolone taper, which resulted in complete remission of the edema and normalization of peripheral blood eosinophil count, serum IL-5 level, IgE, IgM, and LDH.
doi:10.1590/abd1806-4841.20174351 pmid:28954105 pmcid:PMC5595603 fatcat:opsxmvf7arf2vgilaucq3m7pne