Differential expression of BCAT1 in amyotrophic lateral sclerosis [post]

Shahan Mamoor
2022 unpublished
Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines sporadic ALS using published data (3, 4). We found significant differential expression of BCAT1, encoding branched-chain amino acid
more » ... e 1, in iPSC-derived motor neurons of patients with ALS. BCAT1 was also differentially expressed in primary lower motor neurons isolated from patients with ALS. BCAT1 transcript was present at significantly higher levels in ALS iPSC-derived motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
doi:10.31219/osf.io/q7hky fatcat:gukirdxaeza33cwka4x7i5snce