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Appearance of glucose-induced insulin release in fetal rat beta-cells
Journal of Endocrinology
Fetal rat pancreatic cells were isolated from pancreatic primordia on days 12-14 of pregnancy and cultured for 48 h in the presence of 5 mmol/l glucose. Insulin accumulation in the medium over the next 24 h was measured. Cultured cells from day 12 fetuses secreted about 1 fmol insulin per pancreas in response to 5 or 15 mmol/l glucose irrespective of whether 1 mmol/l tolbutamide, 400 µmol/l diazoxide, 5 mmol/l theophylline or 10 mmol/l mannoheptulose was present. In contrast, insulin releaseddoi:10.1677/joe.0.1580115 pmid:9713332 fatcat:vx4mlo6hnfenxf6rdphxu6hedi