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An integrative computational approach to effectively guide experimental identification of regulatory elements in promoters
2012
BMC Bioinformatics
Transcriptional activity of genes depends on many factors like DNA motifs, conformational characteristics of DNA, melting etc. and there are computational approaches for their identification. However, in real applications, the number of predicted, for example, DNA motifs may be considerably large. In cases when various computational programs are applied, systematic experimental knock out of each of the potential elements obviously becomes nonproductive. Hence, one needs an approach that is able
doi:10.1186/1471-2105-13-202
pmid:22897887
pmcid:PMC3465240
fatcat:6dtgu3qe7rgvvlejhvq3jsmkwy