Huntington aggregation inhibitory activities and transglutaminase inhibitory activities of 2APB analogues were measured. 2-APB analogues regulated the Huntington aggregation. This fact provided an example that 2-APB analogues can regulate cellular process. Diphenyl (aminoacidonate N,O) boranes, which are effective regulator of Ca2+ release and cellular process, were effective regulators of Huntington aggregation. It was also found that many of 2-APB analogues have moderate transglutaminase

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... ition activities 2-Aminoethyl di(4-trifluorophenyl) borinate is a good transglutaminase regurator. Keywords : 2-APB; 2-APB analogue; Regulator of transglutaminase; Regulator of huntington aggregation; Huntington disease We have synthesized 493 2-APB analogues [38-43] using methods described by us [38-43] and others [44-49]. The structures, names and synthetic methods of the compounds are in example 1-493 [43].