Protective effect of muramyl dipeptide analogs against infections of Pseudomonas aeruginosa or Candida albicans in mice

E B Fraser-Smith, T R Matthews
1981 Infection and Immunity  
Two analogs of N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) were found to give better protection than muramyl dipeptide against intraperitoneal Pseudomonas aeruginosa infection or intravenous Candida albicans infection in mice. The analogs tested were N-acetyl-nor-muramyl-L-alanyl-Disoglutamine and N-acetylmuramyl-L-a-amino-butyryl-D-isoglutamine. The op-MATERIALS AND METHODS Glycopeptides. MDP and the following analogs of MDP were used in these studies:
more » ... yl-nor-muramyl-L-alanyl-D-isoglutamine (norMDP), N-acetylnor-muramyl -La -aminobutyryl -Disoglutamine ([Abu']norMDP), N-acetylmuramyl-L-a-amino-butyryl-D-isoglutamine ([Abu']MDP), and N-glycolylnor-muramyl-L-alanyl-D-isoglutamine ([N-glycolyl]-norMDP). The nor prefix is used to designate compounds lacking the methyl group on the lactyl portion of the molecule. The compounds were prepared by members of Syn-
doi:10.1128/iai.34.3.676-683.1981 fatcat:vnckahfrcva4jken5j5xwuyn7e