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Interplay among regulators of multidrug resistance in Kluyveromyces lactis
2011
General Physiology and Biophysics
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The KlYAP1 and KlPDR1 genes encode two main transcriptional regulators involved in the control of multidrug resistance in Kluyveromyces lactis. Deletion of KlPDR1 or KlYAP1 genes in K. lactis generated strain hypersusceptible to diamide, benomyl, fluconazole and oligomycin. Overexpression of genes KlPDR1 or KlYAP1 from a multicopy plasmid in the Klpdr1∆ mutant strain increased the tolerance of transformants to all the drugs tested. YRE response elements were found in the promoter of the KlPDR1
doi:10.4149/gpb_2011_si1_77
pmid:21869455
fatcat:nehx6mj5lrfbddyjrfc2ykym34