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Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to supportdoi:10.1093/nar/gkx1132 pmid:29145629 pmcid:PMC5753187 fatcat:2br73vnp4fbhbc3xlejyjmvyh4