Altered Auditory P300 Performance in Parents with Attention Deficit Hyperactivity Disorder Offspring

Mei Hung Chi, Ching-Lin Chu, I Hui Lee, Yi-Ting Hsieh, Ko Chin Chen, Po See Chen, Yen Kuang Yang
<span title="2019-11-20">2019</span> <i title="Korean College of Neuropsychopharmacology"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/k3ewftaqkbglpp2iqaxz6m567i" style="color: black;">Clinical Psychopharmacology and Neuroscience</a> </i> &nbsp;
Altered event-related potential (ERP) performances have been noted in attention deficit hyperactivity disorder (ADHD) patients and reflect neurocognitive dysfunction. Whether these ERP alterations and correlated dysfunctions exist in healthy parents with ADHD offspring is worth exploring. Thirteen healthy parents with ADHD offspring and thirteen healthy controls matched for age, sex and years of education were recruited. The auditory oddball paradigm was used to evaluate the P300 wave complex
more &raquo; ... the ERP, and the Wechsler Adult Intelligence Scale-Revised, Wisconsin Card Sorting Test, and continuous performance test were used to measure neurocognitive performance. Healthy parents with ADHD offspring had significantly longer auditory P300 latency at Fz than control group. However, no significant differences were found in cognitive performance. The presence of a subtle alteration in electro-neurophysiological activity without explicit neurocognitive dysfunction suggests potential candidate of biological marker for parents with ADHD offspring.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.9758/cpn.2019.17.4.509">doi:10.9758/cpn.2019.17.4.509</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31671488">pmid:31671488</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6852684/">pmcid:PMC6852684</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/uec7ov5dsfgjll53d54siezjgm">fatcat:uec7ov5dsfgjll53d54siezjgm</a> </span>
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