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Proceedings of the 2005, American Control Conference, 2005.
Upon uniform stimulation by the chemoattractant cAMP, Dictyostelium cells exhibit a biphasic response. Initially, a rapid rise in the localized accumulation of PI(3,4,5)P 3 is accompanied by an increase in actin polymerization. This response peaks approximately 5-10 seconds after stimulation. It is then followed by a slower, smaller phase peaking approximately two minutes after the stimulus. Until recently, the nature of this biphasic response has been poorly understood. Moreover, the origindoi:10.1109/acc.2005.1470671 fatcat:2nrtvn4p7jcjfmxz3aualsm5ua