The blasts in the peripheral blood is usually associated with a haematological disorder. Study aimed to see if a single blast seen in a peripheral blood film of healthy individuals and patients of non-neoplastic haematological disorders and non-hematological neoplasms/disorders did have any clinical significance. Material and Methods: The period of study was from 2014 to 2018 conducted at a tertiary care hospital. The study was done exclusively on Peripheral Blood Films. The films were stained

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... ith Leishman stain. An occasional blast was detected in some healthy subjects and patients of non-neoplastic haematological disorders and non-hematological neoplasms/ disorders. Result: The routine smears were analyzed with caution after the first case of a patient of Iron Deficiency Anemia revealed a clear-cut Blast. In the period of 4 years from 2014 to 2018, a total of 23 cases of apparently normal individuals or patients with non neoplastic haematological disorders and nonhematological neoplasms/disorders showed at least 1% on one separate occasion. Conclusion: A careful morphological examination in the peripheral smears of few normal individuals and individuals with non neoplastic haematological disorders and nonhematological neoplasms/disorders showed at least 1% Blast on one separate occasion. The cells were clear cut blasts with a large size, fine nuclear chromatin, one to two nucleoli with round to slightly irregular nuclear contours and a mild amount of pale agranular cytoplasm. On thorough investigations of these individuals there was no evidence of a neoplastic haematological disorder. Therefore a single blast in a peripheral blood seen in a healthy individuals or patients with benign haematological disorder and non-neoplastic neoplasms/disorders may not always indicate a neoplastic process.