Single Circulating Blast in the Peripheral Blood Film in Normal Individuals and Patients of Non-neoplastic Haematological Disorders and Non-hematological Neoplasms/Disorders- A Study at a Tertiary Care Centre
International Journal of Contemporary Medical Research [IJCMR]
The blasts in the peripheral blood is usually associated with a haematological disorder. Study aimed to see if a single blast seen in a peripheral blood film of healthy individuals and patients of non-neoplastic haematological disorders and non-hematological neoplasms/disorders did have any clinical significance. Material and Methods: The period of study was from 2014 to 2018 conducted at a tertiary care hospital. The study was done exclusively on Peripheral Blood Films. The films were stained
... films were stained with Leishman stain. An occasional blast was detected in some healthy subjects and patients of non-neoplastic haematological disorders and non-hematological neoplasms/ disorders. Result: The routine smears were analyzed with caution after the first case of a patient of Iron Deficiency Anemia revealed a clear-cut Blast. In the period of 4 years from 2014 to 2018, a total of 23 cases of apparently normal individuals or patients with non neoplastic haematological disorders and nonhematological neoplasms/disorders showed at least 1% on one separate occasion. Conclusion: A careful morphological examination in the peripheral smears of few normal individuals and individuals with non neoplastic haematological disorders and nonhematological neoplasms/disorders showed at least 1% Blast on one separate occasion. The cells were clear cut blasts with a large size, fine nuclear chromatin, one to two nucleoli with round to slightly irregular nuclear contours and a mild amount of pale agranular cytoplasm. On thorough investigations of these individuals there was no evidence of a neoplastic haematological disorder. Therefore a single blast in a peripheral blood seen in a healthy individuals or patients with benign haematological disorder and non-neoplastic neoplasms/disorders may not always indicate a neoplastic process.