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Our view of bacteria, from the earliest observations through the heyday of antibiotic discovery, has shifted dramatically. We recognize communities of bacteria as integral and functionally important components of diverse habitats, ranging from soil collectives to the human microbiome. To function as productive communities, bacteria coordinate metabolic functions, often requiring shifts in growth and development. The hallmark of cellular development, which we characterize as physiological changedoi:10.1146/annurev.micro.091208.073248 pmid:19566421 fatcat:bpstpu7zizczhlnvgmjfcdl4bq