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Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells
During thymic selection'mis-selected' CD8 + T cells exit to the periphery where they are deleted by a Fas/FasL-mediated mechanism, presumably as a result of activation by self-antigens. In the absence of functional FasL, as is the case in autoimmune gld mice, these'mis-selected' T cells develop into unique Thy1 + CD4 ± CD8 ± TCRab + B220 + lymphocytes [abnormal double negative T (DN T) cells]. Using bioactive FasL-bearing vesicles [FasL vesicle preparation (FasL VP)], we were able to inducedoi:10.1093/intimm/dxh078 pmid:15096479 fatcat:dhgybbzyajfv5dfntwshs4fipq