Bone Mineral Density Reduction Following Irradiation of Brain Tumors
Pediatric Neurology Briefs
connectivity is proposed, rather than loss of neurons, to explain the neurological and cognitive deficits in preterm babies. CSF OBSTRUCTION AND MALABSORPTION IN CONGENITAL HYDROCEPHALUS The relative contribution of CSF malabsorption and obstruction in three different etiological groups of neonatal high-pressure hydrocephalus (HC) was assessed in a . CSF biomarkers, transforming growth factor beta-1 (TGF B-l), and aminoterminal propeptide of type 1 collagen (PC1NP), indicative of growth
... e of growth factorand fibrosis-related CSF malabsorption, were assessed and compared in neonates with post-hemorrhagic HC (n=6), non-hemorrhagic biventricular HC (n=4) and spina bifida (SB) HC (n=12). CSF interleukin-6 (IL-6) cytokines, indicative of inflammation, were low and did not differ between groups. TGF B-l concentrations were significantly higher in post-hemorrhagic HC cases (median 355 pg/ml) than in SB HC (median 103) and non-hemorrhagic HC (median 120); p=0.01 and 0.03, respectively. Median CSF PC1NP concentrations were significantly lower in SB HC (180 ng/ml) than in post-hemorrhagic HC (1,060 ng/ml); p=0.002. Neonatal posthemorrhagic HC is associated with high concentrations of CSF malabsorption-related biomarkers whereas SB and non-hemorrhagic HC have lower concentrations, indicating that CSF obstruction contributes more to the development of these cases than malabsorption. (Heep A, Bartmann P, Stoffel-Wagner B et al. Cerebrospinal fluid obstruction and malabsorption in human neonatal hydrocephaly. . COMMENT. High TGF B-l and PC1NP CSF concentrations in neonatal post¬ hemorrhagic HC are indicative of a fibrosis-related malabsorption as the cause of the HC, contrasting with relatively low levels of malabsorption biomarkers in SB and nonhemorrhagic biventricular HC. CSF obstruction, rather than malabsorption, plays a major role in the pathogenesis of high-pressure SB and non-hemorrhagic HC.