SYNTHESIS OF POLYMERIC NANOPARTICLE "PNIPAM" POLY (N-ISOPROPYLACRYLAMIDE) AND THEIR TOXICITY ASSAY ON SWISS ALBINO MICE Mus musculus

Imtiyaz Aslam, Rohit Verma, S Roy
2013 Indian Journal of Fundamental and Applied Life Sciences   unpublished
Through the application of Nanotechnology for development of functional nanoparticles with nanometric dimensions has attracted growing interests in fundamental as well as applied sciences. The nanoparticles are highly potent and are widely used in Medical Sciences as drug carriers. In the present study the polymeric nanoparticle viz-PNIPAM, a thermo-sensitive polymer has been synthesized. The characterization result of prepared nanoparticle reveals that the nanoparticle is about 150 nm in
more » ... out 150 nm in diameter. The toxicity assay of the nanoparticle has been carried out in Swiss albino mice Mus musculus for finding the possible applications of these nanoparticles as targeted drug delivery system. The nanoparticles have large surface area per unit volume and this characteristic is explored for the application of targeted drug delivery to the various organs. The ligands are adsorbed on the nanoparticle for the targeted delivery. The tolerance of the amount by the organisms should be determined before using the nanoparticle for the drug delivery vehicle and the permissible level should be administered to achieve the desired effectiveness of the drug.
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