Stereochemistry, Syntheses and Biological Activity of Lupine Alkaloids—from Studies on the Leguminous Plants Growing Mainly in Japan

Shigeru OHMIYA
2007 Yakugaku zasshi  
Lupine alkaloids have been studied from the viewpoints of biosynthesis, biotechnology, chemotaxonomy, and biological activity, on the basis of the chemical investigation of the leguminous plants of the 28 species belonging to the 9 genera, which mainly grow in Japan. The results obtained have been comprehensively reviewed by authors. This review describes the stereochemistry of lupine alkaloids and focuses on the conformational ‰exibility of nitrogen-fused systems such as quinolizidine and
more » ... nolizidine and indolizidine, syntheses of new unusual types of alkaloids from known lupine alkaloids, and pharmacological activity of lupine alkaloids, especially k-opioid receptor-mediated antinociceptive eŠects of matrinetype lupine alkaloids.
doi:10.1248/yakushi.127.1557 pmid:17917418 fatcat:wwoo4ima5nb5jcf526aqswj6te