Antioxidant and hepatoprotective activity of Piper retrofractum against Paracetamol-induced hepatotoxicity in Sprague-Dawley rat

Kamanashis Mahaldar, Amir Hossain, Fahrima Islam, Sharmin Islam, Md. Amirul Islam, Masum Shahriar, Md. Mustafizur Rahman
2019 Figshare  
The ethanol extracts of Piper retrofractum were investigated for antioxidant and hepatoprotective activity. Hepatoprotective activity against paracetamol-induced acute hepatotoxicity was estimated in Sprague-Dawley rat. In DPPH free radical assay the root and stem extracts showed IC50 values at 133 and 91 µg/mL, respectively, while ascorbic acid at 14 µg/mL. Extracts also exhibited hydroxyl radical scavenging activity and reducing power. HPLC-DAD analysis indicated the presence of some
more » ... lic compounds. Treatment of extracts significantly reduced the elevated serum levels of GPT (P P P
doi:10.6084/m9.figshare.7608845.v1 fatcat:ex3p5aok6zhzrak2hhm4slhk5m