Hypercoagulability in different respiratory diseases

Howida Mohamed Abd Elsalam, Mohamed Awad Mohamed, Mohamed Sobh El Gammal, Mohammed El-Shabrawy
2013 Egyptian Journal of Chest Disease and Tuberculosis  
The risk of venous thromboembolism (VTE) is equally high in medical patients admitted to the hospital and those treated in the surgery wards. Patients who are immobilized due to heart failure, severe respiratory disease, cerebrovascular stroke and cancer are at a high risk of venous thrombosis. Aim of the work: The aim of the study was to assess the impact of different respiratory insults on blood coagulation for early detection and prevention of thrombosis to open the way for
more » ... in such cases. Patients and methods: The study included 25 apparently normal healthy control subjects and 141 patients with different respiratory disorders. All patients were subjected to full medical history taking, full clinical examination, and radiological evaluation. Computed tomography (CT) pulmonary angiography was done for all cases and lower limb duplex ultrasonography for all patients, at day 1 and day 5 of admission. The following coagulation markers were evaluated for all patients at day 1, 2,3,4, and 5 of admission including: Soluble fibrin complex, D dimer, thrombin antithrombin complex, antithrombin, protein C, protein S, and fibrinogen. Results: It was found that, the mean values of soluble fibrin complex, D dimer and thrombin antithrombin complex were higher in patients with positive duplex ultrasonograghy and positive CT angiography than patients with negative duplex ultrasonograghy and CT angiography and the difference was statistically highly significant. The higher mean values for soluble fibrin complex was on the third day of admission, while the higher mean values for D dimer, thrombin antithrombin
doi:10.1016/j.ejcdt.2013.06.002 fatcat:pofxfw4g3rbbvkyrejsnytfjla