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In this paper we present an ontology-based clinical decision-support framework for handling comorbidities by alignment of ontology modeled clinical practice guidelines (CPG). Our knowledge management approach to develop clinical decision support systems for co-morbid conditions entails: (a) knowledge synthesis to derive disease-specific clinical pathways (CP) from evidence-bases sources; (b) knowledge modeling to abstract medical and procedural knowledge from the CP; (c) knowledgedoi:10.1109/hicss.2012.629 dblp:conf/hicss/AbidiCAS12 fatcat:wsoiewwbrzdqpnlekloixthvea