A case of chronic pancreatitis complicated by marked pancreatic calcification in patients with severe motor and intellectual disabilities
著明な膵石灰化を伴う慢性膵炎を合併した重症心身障害者の一例

Hiromitsu Ohmori, Takayuki Fukuhara, Masami Yamasaki, Yoshio Murata, Hiromasa Fukuba, Masahiko Takemoto, Masanobu Ikeda, Nobuo Matsumoto, Shoichi Tanaka, Ryo Sumimoto
2014 Japanese Journal of Severe Motor and Intellectual Disabilities  
Chronic pancreatitis is a progressive inflammatory disorder in which the pancreatic secretory parenchyma is destroyed and replaced by fibrous tissue, which eventually leads to malnutrition, and pancreatic exocrine and endocrine dysfunction. On the other hand, patients with severe motor and intellectual disabilities (SMID) have the complication of a high incidence of epilepsy, most of them having intractable epilepsy. We have reported chronic pancreatitis with the complication of marked
more » ... c calcification in an epileptic patient with SMID, who had exhibited cerebral palsy and undergone gastrostomy feeding due to difficulty in swallowing. Clinically, he had no remarkable digestive symptoms and the laboratory findings indicated maintenance of pancreatic functions in the normal ranges. The two main types of chronic pancreatitis are basically regarded as being alcoholic and non-alcoholic. Furthermore, as causative factors of drug-induced pancreatitis, valproic acid, phenacitin, thiazide, oestrogen, and azathioprine are known. In the present case, the treatment with multidrug therapy, including valproic acid for intractable epilepsy was performed, and the causative factor for the chronic pancreatitis was strongly suggested to be drugs. Therefore, in intractable epileptic patients with SMID, great care should be taken regarding chronic pancreatitis such as in this case.
doi:10.24635/jsmid.39.1_125 fatcat:c5ukq6x6xbbvbfsydiddffiagy