A Randomized Controlled Trial on Safety and Efficacy of Single Intramuscular versus Staggered Oral Dose of 600 000IU Vitamin D in Treatment of Nutritional Rickets

K. Mondal, A. Seth, R. K. Marwaha, D. Dhanwal, S. Aneja, R. Singh, P. Sonkar
2014 Journal of Tropical Pediatrics  
Objective: Comparison of efficacy and safety of two different regimens of vitamin D-600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets. Methods: Children with nutritional rickets (age: 0.5-5 years, n ¼ 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25
more » ... hydroxy vitamin D and radiological score were compared at 12-week follow-up. Results: No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D >100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment. Conclusion: Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets.
doi:10.1093/tropej/fmt105 pmid:24401754 fatcat:fw5ezmallnag3o75z7r2f3pwqe