Synthesis and pharmacological activities of some new 1-substituted-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles Organic CHEMISTRY Organic CHEMISTRY

Sabir Hussain, Deepika Kaushik, An Journal
2011 OCAIJ   unpublished
Several-1-carbothioamide-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles (2a-d), 1-(pyridine-4-ylcarbonyl)-3,5-dimethyl-4-[(substituted phenyl) diazenyl] pyrazoles (3a-d), were synthesized. The structures of the newly synthesized compounds were supported by IR, 1 H NMR and Mass spectral data. These compounds were investigated for their, anti-inflamma-tory, analgesic, ulcerogenic, lipid peroxidation, antibacterial and antifungal activities. Some of the synthesized compounds showed
more » ... pounds showed potent anti-inflam-matory activity along with minimal ulcerogenic effect and lipid peroxidation, compared to ibuprofen and flurbiprofen. Some of the tested compounds also showed moderate antimicrobial activity against tested bacterial and fungal strains. 