Objectives: A) Evaluate the clinical-pathological characteristics of malignant neoplasms of salivary glands: A.1) Quantify the numbers of which tumor subtype. A.2) Gender, age and the type of salivary gland influence tumor behavior? A.3) Describe 16 years of evolution in a target portuguese population. B) What are the treatments chosen in which subtype? C) What is the prognosis? And what can influence the prognosis? Study Design: A 16-year retrospective study of 138 patients with salivary gland

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... tumors from 2000 to 2016 in the Anatomical Pathology Department of Centro Hospitalar do Porto, Hospital Geral de Santo António. The histological diagnoses - according to the 2017 World Health Organization classification. Results: In the present study, we revised all the cases of salivary gland pathology from 396 cases. A total of 138 tumors were identified in 91 male and 47 female patients. The mean age was 58 years. The frequency of major salivary gland tumors was 56.3%, and that of minor salivary gland tumors was 43.7%. Mucoepidermoid carcinoma was the most common malignant tumor. Conclusions: Knowledge of the different clinic characteristics is important and essential to a better prognosis and in many cases a reduction of the mortality.