Prevalence of Brain Metastases Immediately before Prophylactic Cranial Irradiation in Limited Disease Small Cell Lung Cancer Patients with Complete Remission to Chemoradiotherapy: A Single Institution Experience

Farkhat Manapov, Gunther Klautke, Rainer Fietkau
2008 Journal of Thoracic Oncology  
This single-center study investigated the prevalence of brain metastases immediately before prophylactic cranial irradiation in 40 consecutive limited disease small cell lung cancer complete responders to chemoradiotherapy and revealed that 13/40 (32.5%; 95% confidence interval: 18 -47%) patients suffer relapse with brain metastases and show a significantly worse prognosis than those without detected brain metastases.
doi:10.1097/jto.0b013e3181757a76 pmid:18520807 fatcat:zs3dnbywr5dpjoh7mcvhg2jog4