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Effects of Betamethasone and Gentamicin on Renal Scarring Induced by Mannose-Sensitive E Coli Pyelonephritis in Rat Original Article Effects of betamethasone and gentamicin on renal scarring in rat 131
Pyelonephritis can lead to renal scar. Objective: To evaluate the effects of betamethasone in preventing renal scarring in rat model of pyelonephritis. Methods: Sixty three female Sprague-Dawley rats were divided into seven groups. Group A was the control. Mannose-sensitive E coli was directly inoculated into the left kidney exposed under general anesthesia in groups C-G. Group B received normal saline. Two days after bacterial inoculation, groups C, E and F received gentamicin for 10 days.fatcat:5rrbqgyc7vhhlbmt7cpxyhzcly