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During the course of a lifetime somatic cells acquire mutations. Different mutational processes may contribute to the mutations accumulated in a cell, with each imprinting a mutational signature on the cell's genome. Some processes generate mutations throughout life at a constant rate in all individuals and the number of mutations in a cell attributable to these processes will be proportional to the chronological age of the person. Using mutations from 10,250 cancer genomes across 36 cancerdoi:10.1038/ng.3441 pmid:26551669 pmcid:PMC4783858 fatcat:uk7adilqjvcwjofhfbc4p6b3eq