Central Mediation of Hormonal Influences on Instrumental Avoidance Conditioning [chapter]

F. R. Brush, S. M. Fraley
1980 The Warsaw Colloquium on Instrumental Conditioning and Brain Research  
Two behaviorally active harmones of the pituitary-adrenal system are adrenocorticotropic hormones (ACTH) and corticosterone, and their behavioral effects are facilitation and inhibiftion of performance of previously learned avoidance responses, respectively. Their uptake, distribution and effects on central nervous system are reviewed. Hypothalamic neurotransmitter control of corticotropin releasing hormone (CRH) is described together with hypothalamic and extra-hwothalamic (hippocampal)
more » ... hippocampal) regulation of pituitary-adrenal activity. Extra-hypothalamic mediation of the behavioral effects of ACTH is evaluated. Recent isotopic mappings of the efferents of the hippocampal formation have identified pathways from hippocampal subiculum to hypothalamus and posterior lateral and anterior thalamic nuclei. The evidence reviewed suggests a complex circuit Bnvolving hippocampal subiculum, thalamus and hypothalamus may be involved both in regulating pituitary-adrenal responses to stress and in mediating the effects of ACTH on avoidance behavior.
doi:10.1007/978-94-009-8225-3_25 fatcat:6ks2zzthffbqjirkbltu55pj7q