Calcite nano-particle is suggested as an extremely effective material in the biomedical due to their shape, non-toxic properties and being easily metabolized by cells. In clinical application, calcite nano- particle has to be useful for recovering the surface of tooth. The surface of tooth was often damaged due to wrong tooth care treatment, dental caries and periodontal disease. Because of tooth surface destruction, it could lead to dental hypersensitivity. It is desirable to find a suitable

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... urce for supplying calcium to fill in dentinal tubules and later regenerate the tooth surface. This study demonstrated the synthesis and characterization of calcite nano-particle for its application in dental hypersensitivity treatment. Cockleshell was found to be a suitable source to synthesize calcite. Using cockleshell as raw materials to produce calcite nanoparticle is meaningful for both environmental protection and biomedical application. Therefore, in this study, calcite nano-particle was synthesized using cockleshell as a reproducibility source of calcium carbonate (CaCO3) and chitosan as a size-reducing agent. X-ray Diffraction (XRD) was used to characterize phase composition of raw materials, as-prepared powder and calcined powder. Transmission Electron Microscopy (TEM) was used to evaluate the size and morphology of powder. Results indicated that calcite nano-particle with size about 50-100 nm could be obtained. It would be expected to consider for further studies in clinical application.