Dual drug delivery device for chronic pain management using micromachined elastic metal structures and silicon microvalves

Allan T. Evans, Jong M. Park, Srinivas Chiravuri, Yogesh B. Gianchandani
2008 Micro Electro Mechanical Systems (MEMS), Proceedings of the IEEE International Conference on  
This paper describes a dual-chamber drug delivery microsystem that provides regulated flow from two springpressurized balloon reservoirs using independent microvalves. A preliminary prototype has been constructed with the primary components. Micromachined bulk metal springs (Co-Ni-Cr alloy), with an in-plane spring constant exceeding 300 N/m, are used in conjunction with 18.8 mL reservoirs, and provide 15 kPA pressure when the balloons are fully inflated. A piezoresistive pressure sensor that
more » ... ssure sensor that is embedded in the microvalves monitors reservoir pressure with a sensitivity of 250 ppm/kPa, and is used to regulate bolus delivery. Two control plans for the valve and their respective limitations are presented. In a demonstration of regulated bolus delivery, 1.5 mL bolus doses are delivered at different rates.
doi:10.1109/memsys.2008.4443640 fatcat:2v6ujr7t45fabktamiurk6x4pm