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Ermann CD4 ؉ CD25 ؉ regulatory T cells (T reg ) acquire unique immunosuppressive properties while maintaining an anergy phenotype when activated in vitro under conditions that induce IL-2 production and proliferation in conventional CD4 ؉ T cells. We investigated the mechanism underlying one component of this naturally anergic phenotype, the inability of the T reg cells to produce IL-2 following activation. Analysis of freshly isolated murine CD4 ؉ CD25 ؉ T reg and conventional CD4 ؉ CD25 ؊ Tdoi:10.4049/jimmunol.173.8.4994 pmid:15470042 fatcat:b3pi56cvojgnxlcbxilmmqvuwi