A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
Controlling the behaviour of cells by rationally guiding molecular processes is an overarching aim of much of synthetic biology. Molecular processes, however, are notoriously noisy and frequently non-linear. We present an approach to studying the impact of control measures on motifs of molecular interactions, that addresses the problems faced in biological systems: stochasticity, parameter uncertainty, and nonlinearity. We show that our reachability analysis formalism can describe the potentialdoi:10.1098/rsos.160790 pmid:28878957 pmcid:PMC5579072 fatcat:wwdkzpekvvdfrijkaq4d3h26cm