Background:Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. About 40% NSCLC patients develop bone metastasis. The aberrant expression of IGF2 (insulin-like growth factor-2) is known to be linked with many malignancies, but it has not been reported in NSCLC. Methods and Results:We first used the GEO database for differential gene analysis and showed a correlation between IGF2 and bone metastasis in NSCLC. IGF2 was highly expressed in primary NSCLC and

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... n more highly expressed in bone metastases. Our in vivo experiment also showed that IGF2 promoted lung cancer proliferation and migration. In addition, IGF2 overexpression activated AKT/NF-κB pathway by promoting IGF1R and INSR phosphorylation, and enhanced osteolytic lesions in lung cancer.Conclusions:Up-regulation of insulin-like growth factor-2 can promote the proliferation and migration of non-small cell lung cancer cells, and is related to bone metastasis.