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The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury
In patients with abdominal region cancers, ionizing radiation (IR)-induced long-term liver injury is a major limiting factor in the use of radiotherapy. Previously, the major mitochondrial deacetylase, sirtuin 3 (SIRT3), has been implicated to play an important role in the development of acute liver injury after total body irradiation but no studies to date have examined the role of SIRT3 in liver's chronic response to radiation. In the current study, ten-month-old Sirt3−/− and Sirt3+/+ maledoi:10.3390/antiox9050409 pmid:32403251 fatcat:4nugxhjd3fgtpfzik4xlqstljm