The authors examined IgF-1 plasma levels in 113 patients with Down Syndrome (DS) (68 males and 45 females, aged 1-23.66 years), all without severe congenital malformations, malnutrition, coeliac disease, alterations in thyroid or adrenal function, or taking any medication which might affect the study. The authors used a radioimmunoassay (RIA) method with plasma previously treated by acid-ethanol extraction and correlated the IgF-1 plasma levels with age and BMI (Body Mass Index) using multiple

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... egression analysis. The BMI was higher in Down syndrome compared with normal subjects (NS), both in males (p=0.000006) and females (p= 0.034829). The two groups showed a positive correlation of IgF-1 levels with age. However, no correlation was found between IgF-1 levels and BMI.