Antineoplastic 31-Norcycloartanones from Solanum cernuum Vell

Rogério Grando, Marcia A. Antônio, Carlos E. P. Araújo, Catarina Soares, Maria A. Medeiros, João E. de Carvalho, Ana M. Lourenço, Luciane C. Lopes
2008 Zeitschrift für Naturforschung C - A Journal of Biosciences  
Triterpenoids with 31-norcycloartanone structure were isolated for the first time from the Solanum genus. Cycloeucalenone and 24-oxo-31-norcycloartanone were the main constituents of the dichloromethane extract of Solanum cernuum Vell. leaves [7% (w/w) and 1.47% (w/w)]. Both triterpenoids were tested against human tumour cell lines, and 24-oxo-31-norcycloartanone was significantly active and selective against the lung tumour cell line NCI-H460 with total growth inhibition at 1.10 μg/mL, growth
more » ... 1.10 μg/mL, growth inhibition 50 at 0.19 μg/mL and lethal concentration 50 at 8.43 μg/mL, while cycloeucalenone showed poor activity. A homologous series of alkanes (C25-C34), β-sitosterol, and the xanthophyll lutein were also identified. The antiulcer activity was assayed for the dichloromethane extract. In the gastric ulcer model induced by 95% ethanol, administration of 500, 1000 and 2000 mg/kg/po dichloromethane extract gave ulcer lesion indices of, respectively, 38.2, 61.0 and 81.9%, while carbenoxolone inhibited 88.9% at 200 mg/kg. In the gastric ulcer model induced by indomethacin the dichloromethane extract showed a small percentage of lesion inhibition. The ethanol extract was also analyzed and was mainly composed of glycoalkaloids, peptides and disaccharides.
doi:10.1515/znc-2008-7-807 fatcat:tmzixpkbofclrceodhcbjxndve