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Rhabdoid tumours (RTs) are highly aggressive tumours of infancy, frequently localized in the central nervous system (CNS) where they are termed atypical teratoid/rhabdoid tumours (AT/RTs) and characterized by bi-allelic inactivation of the SMARCB1 tumour suppressor gene. In this study, by temporal control of tamoxifen injection in Smarcb1 flox/flox ; Rosa26-Cre ERT2 mice, we explore the phenotypes associated with Smarcb1 inactivation at different developmental stages. Injection before E6, atdoi:10.1038/ncomms10421 pmid:26818002 pmcid:PMC4738337 fatcat:uvafgadp5jc3jlumuxkzphot2y