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Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease
2021
Neurobiology of Aging
Matrix metalloproteinases (MMPs) are a multigene family of proteinases regulating the functions of a large number of signaling and scaffolding molecules that are involved in neuro-inflammation, synaptic dysfunction and neuronal death. MMPs have been associated with neurological conditions, such as Alzheimer's disease (AD), through a sudden and massive upregulation of particular members of the MMP family. Evidence for this hypothesis can be found in the clinical observation of increased MMP1 and
doi:10.1016/j.neurobiolaging.2021.03.011
pmid:33892965
fatcat:k4pakrav5ncshohldbj4opo2rq