A novel PEG–haloperidol conjugate with a non-degradable linker shows the feasibility of using polymer–drug conjugates in a non-prodrug fashion

Felicity Heath, Amy Newman, Chiara Clementi, Gianfranco Pasut, Hong Lin, Gary J. Stephens, Benjamin J. Whalley, Helen M. I. Osborn, Francesca Greco
2016 Polymer Chemistry  
A PEG–haloperidol conjugate was synthesised, which retains binding to the dopamine D2 receptor, showing the possibility of using polymer-drug conjugates as drugs per se' rather than as prodrugs.
doi:10.1039/c6py01418f fatcat:y6qbrebyyvdk3hbs4nb7lqfrou