Transmigration of Lymph Nodes by Tumor Cells

B. Fisher, E. R. Fisher
1966 Science  
counting cells on selected histological sections (3, 4) is subject to error in interpretation because the result does not give information about the increase in the total number of cortical cells unless it is assumed that this increase is similar in all directions. Clendinnen and Eayrs (5) have repeated some of these experiments (subcutaneous injection of pituitary growth hormone into pregnant rats) and found in the mature offspring a 20-percent increase in the cell-gray coefficient, 23percent
more » ... ficient, 23percent increase in the mean number of dendrites, and a 22-percent -increase in the mean length of dendrites; these changes were statistically significant. The estimated probability of interaction between an extended axonal system and dendritic field had increased by 55 percent. These animals showed a statistically significant enhancement in the performance of cortically mediated behavior (closed-field Hebb-Williams test). Berry, Rogers, and Eayrs (2) subsequently suggested that the addition of the superficial laminae, and
doi:10.1126/science.152.3727.1397 pmid:5949244 fatcat:apg6odmhtzbg5d2huaey2fomau