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Differential distribution of VGF-derived peptides in the adrenal medulla and evidence for their selective modulation
2008
Journal of Endocrinology
While vg f gene knockout mice are hyperactive and hypermetabolic, surprisingly the TLQP-21 brain VGF peptide increased energy consumption, suggesting that opposing regulatory effects could be exerted by peptides alternatively cleaved from the VGF precursor. Using antisera to the VGF precursor C-terminus and three cleavage products, we revealed a distinct differential distribution in adrenal, certain peptides (VGF422–430: PGH peptides) being found throughout bovine and swine medulla, while
doi:10.1677/joe-07-0346
pmid:18434366
fatcat:hnqae3pfsjhopjcubs5ozayti4