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Epilepsy is a paroxysmal neurological disorder characterized by recurrent and unprovoked seizures affecting approximately 50 million people worldwide. Cognitive dysfunction induced by seizures is a severe comorbidity of epilepsy and epilepsy syndromes and reduces patients' quality of life. Seizures, along with accompanying histopathological and pathophysiological changes, are associated with cognitive comorbidities. Advances in imaging technology and computing allow anatomical and topologicaldoi:10.3389/fnana.2018.00025 pmid:29681801 pmcid:PMC5898178 fatcat:a7lzlw3qhfgktalrl2pntv3yb4