Preoperative Prognostic Features of Pancreatic Head Adenocarcinoma
Open Access Journal of Surgery
Objective: The purpose of this study was to define the preoperative prognostic features in pancreatic cancer patients of Whipple procedure. Methods: The medical records of pancreatic head adenocarcinoma patients who underwent Whipple procedure by a single surgeon from 2003 -2012 were reviewed. The cases were retrogradely analyzed in 2 groups: Group 1 (n=9) comprised of patients who lived more than 3 years, and Group 2 (n=13) comprised who died within 1 year following the surgery. Clinical data
... ery. Clinical data were collected by chart review, including demographic, histopathologic, preoperative, perioperative, and postoperative findings. Anova microsoft excel statistic analysis was performed on the recorded data. Results: Patients in Group 2, who survived less than 1 year following surgery, had statis-tically significant more poorly differentiated adenocarcinoma and less dilatation of the pancreatic duct. These patients were more often to have preoperative abdominal/back pain, weight loss and higher level of CA19-9, as compared with those of Group 1 patients. Both groups showed most patients died due to metastatic disease. Conclusion: Pancreatic adenocarcinoma is not a homogeneous disease. It is possible to find preoperative prognostic features for more appropriate management. With better preoperative stratification, the care for these patients could be more individualized, and lead to better outcome.