The Quest for Neuroprotection for Injuries in the Developing Brain

Fatima Yousif Ismail, Ali Fatemi, Michael Johnston
<span title="2017-09-21">2017</span> <i title="The International Child Neurology Association (ICNA)"> <a target="_blank" rel="noopener" href="" style="color: black;">Journal of International Child Neurology Association</a> </i> &nbsp;
The advancement in medical knowledge could have not been possible without interlocking and reinforcing the bedside-lab continuum. In the field of pediatric neurology, one of the best illustrative examples is our quest for finding neuroprotective therapies in the setting of neonatal hypoxic-ischemic encephalopathy. In this review, we discuss the careful clinical observations driven from the bedside dating back to the work of Frank Ford. We trace the relentless efforts to emulate the pathogenesis
more &raquo; ... in animal models to testing potential therapies in clinical trials that made the transfer of this knowledge back to the bedside possible in order to save and improve the quality of life for hundred of thousands of newborns who suffered hypoxic ischemic insult.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.17724/jicna.2017.79</a> <a target="_blank" rel="external noopener" href="">fatcat:6tymhrschrftlmavo2xwngzcny</a> </span>
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