Coupling Within-Host and Between-Host Infectious Diseases Models

Maia Martcheva, Necibe Tuncer, Colette St Mary
2015 Biomath  
Biological processes occur at distinct but interlinked scales of organization. Yet, mathematical models are often focused on a single scale. Recently, there has been a significant interest in creating and using models that link the withinhost dynamics and population level dynamics of infectious diseases. These types of multi-scale models, called immuno-epidemiological models, fall in four categories, dependent on the type of the epidemiological component of the model: network or individual
more » ... or individual based models (IBM), "nested" age-sinceinfection structured models, ordinary differential equation (ODE) models, and "size-structured" models. Immuno-epidemiological multi-scale models have been used to address a variety of questions, including what is the impact of within-host dynamics on population-level quantities such as reproduction number and prevalence, as well as questions related to evolution of the pathogen or co-evolution of the pathogen and the host. Here we review the literature on immuno-epidemiological modeling as well as the main insights these models have created.
doi:10.11145/j.biomath.2015.10.091 fatcat:nqag4ot675ggpm5vprslzyg23m