Enhanced Optics for Time-Resolved Singlet Oxygen Luminescence Detection

Konstantinos Tsimvrakidis, Nathan R. Gemmell, Kleanthis Erotokritou, Shigehito Miki, Masahiro Yabuno, Taro Yamashita, Hirotaka Terai, Robert H. Hadfield
2019 IEEE Journal of Selected Topics in Quantum Electronics  
Singlet oxygen luminescence dosimetry (SOLD) is a highly promising direct monitoring method for photodynamic therapy (PDT) in the treatment of cancer. Early SOLD systems have been hampered by inefficient excitation, poor optical collection and immature infrared single photon detection technology. We report carefully engineered improvements addressing all of these deficiencies. We use a supercontinuum source with a tunable filter to precisely target the peak absorption wavelength of the chosen
more » ... otosensitizer; we have designed a compact and versatile optical package for precise alignment; we have successfully employed state-ofthe-art superconducting photon counting technologies. Through these improvements, we can achieve histogram acquisition from a photosensitizer in solution test sample. This setup opens the pathway to physiological SOLD studies for PDT dosimetry.
doi:10.1109/jstqe.2018.2836962 fatcat:z3lynbrt7nhkld4mowzoq2cpse