Global chemokine expression in methylmercury-treated mice: methylmercury induces brain-specific expression of CCL3 and CCL4

Min-Seok Kim, Tsutomu Takahashi, Jin-Yong Lee, Gi-Wook Hwang, Akira Naganuma
2013 Journal of Toxicological Sciences  
chemokine gene, the CCL4 gene. In this study, we investigated the changes in gene expression levels of all chemokines in various tissues (cerebellum, cerebrum, kidney, liver, and spleen) of methylmercurytreated mice. We found that methylmercury induced upregulation of the CCL4 gene and the CCL3 gene, selective damage by methylmercury in the central nervous system.
doi:10.2131/jts.38.925 pmid:24213012 fatcat:5tbfataeizcmlfsemkaicnolra