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Journal of Current Pharma Research
The present study was designed to synthesise some novel derivatives of 1, 4-thiazines by using o-amino thiophenol with maleic anhydride. Further four Mannich bases were synthesised from 3oxo-3, 4-dihydro-2H-1, 4-benzothiazin-2-yl) acetic acid with sulpha drugs, ethanol and formaldehyde. Then synthesised Mannich bases were docked against Dihydrofolate reductase complexed with NADPH and 6-methyl-5-[3-methyl-3-(3,4,5-trimethoxyphenyl) but-1-yn-1-yl] pyrimidine-2,4-diamine (UCP115A)using Argus Labdoi:10.33786/jcpr.2017.v07i02.002 fatcat:gsgpmuxb55gzzbltgi3ob7m34y