Intrinsic Resting-State Functional Connectivity in the Human Spinal Cord at 3.0 T

Oscar San Emeterio Nateras, Fang Yu, Eric R. Muir, Carlos Bazan, Crystal G. Franklin, Wei Li, Jinqi Li, Jack L. Lancaster, Timothy Q. Duong
2016 Radiology  
Purpose-To apply resting-state functional magnetic resonance (MR) imaging to map functional connectivity of the human spinal cord. Materials and Methods-Studies were performed in nine self-declared healthy volunteers with informed consent and institutional review board approval. Resting-state functional MR imaging was performed to map functional connectivity of the human cervical spinal cord from C1 to C4 at 1 × 1 × 3-mm resolution with a 3.0-T clinical MR imaging unit. Independent component
more » ... lysis (ICA) was performed to derive resting-state functional MR imaging z-score maps rendered on two-dimensional and three-dimensional images. Seed-based analysis was performed for cross validation with ICA networks by using Pearson correlation. Results-Reproducibility analysis of resting-state functional MR imaging maps from four repeated trials in a single participant yielded a mean z score of 6 ± 1 (P < .0001). The centroid coordinates across the four trials deviated by 2 in-plane voxels ± 2 mm (standard deviation) and up to one adjacent image section ± 3 mm. ICA of group resting-state functional MR imaging data revealed prominent functional connectivity patterns within the spinal cord gray matter. There were statistically significant (z score > 3, P < .001) bilateral, unilateral, and intersegmental correlations 1 Supported in part by NIGMS MBRS-RISE GM060655 fellowship.
doi:10.1148/radiol.2015150768 pmid:26505923 pmcid:PMC5425154 fatcat:fo5p2sawwzdh7nfpphgudlyhiu