The Synthesis of Agent Produced by Interaction of the Complex Trans-Dichlorodiamminplatinum(II) with Arabinogalactan and its Properties
Получение препарата на основе взаимодействия соли транс-дихлородиамминплатины(II) с арабиногалактаном и его свойства

Alexander K. Starkov, Galina A. Kozuchovskaya, Nina I. Pavlenko
2016 Journal of Siberian Federal University Chemistry  
The obtained new product of reaction of the complex trans-dichlorodiaminplatinum(II) with arabinogalactan was characterized by XRD, IR-spectroscopy, UF-spetrophotometry and thermogravimetry. The composition and structure of this product was studied. It has been shown that trans-dichlorodiaminplatinum(II) associated with arabinogalactan through -C-O-C-amino hydrogen of the original complex. The synthesized product has the improved pharmacological properties being more soluble, less toxic and
more » ... s a greater anticancer activity as compared to cis-dichlorodiaminplatinum(II).
doi:10.17516/1998-2836-2016-9-1-42-48 fatcat:hbhnqono65bjvlcgc7m2oalv2m